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[Dunia] Saintis Jerman temui punca blood clots dlm Astra dan JJ.Ada kaitan dgn potong n

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Post time 4-6-2021 10:09 AM From the mobile phone | Show all posts |Read mode
Scientists in Germany claim to have cracked the cause of the rare blood clots linked to the Oxford/AstraZeneca and Johnson & Johnson coronavirus vaccines and believe the jabs could be tweaked to stop the reaction happening altogether.

Rolf Marschalek, a professor at Goethe university in Frankfurt who has been leading studies into the rare condition since March, said his research showed the problem sat with the adenovirus vectors that both vaccines use to deliver the genetic instructions for the spike protein of the Sars-Cov-2 virus into the body.

The delivery mechanism means the vaccines send the DNA gene sequences of the spike protein into the cell nucleus rather than the cytosol fluid found inside the cell where the virus normally produces proteins, Marschalek and other scientists said in a preprint paper released on Wednesday.

Once inside the cell nucleus, certain parts of the spike protein DNA are spliced, or split apart, creating mutant versions, which are unable to bind to the cell membrane where important immunisation takes place. The floating mutant proteins are instead secreted by cells into the body, triggering blood clots in roughly one in 100,000 people, according to Marschalek’s theory.

In contrast, mRNA-based vaccines, such as the jabs developed by BioNTech/Pfizer and Moderna, deliver the spike’s genetic material to the cell fluid and it never enters the nucleus.

“When these...virus genes are in the nucleus they can create some problems,” Marschalek told the Financial Times.

The rare blood-clotting reaction that has disrupted the rollout of the AstraZeneca and J&J shots has been recorded in 309 of the 33m people who have received the AstraZeneca vaccine in the UK, causing 56 deaths. In Europe, at least 142 people have experienced the blood clots out of 16m recipients of the vaccine.

In response, use of the AstraZeneca jab has been restricted or suspended in more than a dozen countries. J&J began the rollout of its vaccine in Europe with a warning on its label in April after a brief delay because of the concerns

https://www.ft.com/content/f76eb802-ec05-44...56-b250115d0577

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Post time 4-6-2021 10:11 AM | Show all posts
Potong apa ni. I dont understandf.
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Post time 4-6-2021 10:13 AM From the mobile phone | Show all posts
So, Malaysia patut halt dulu AZ until AZ keluarkan version baru.
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 Author| Post time 4-6-2021 10:36 AM From the mobile phone | Show all posts
tipahketipung replied at 4-6-2021 10:11 AM
Potong apa ni. I dont understandf.

certain parts of the spike protein DNA are spliced, or split apart, creating mutant versions,
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Post time 4-6-2021 10:48 AM From the mobile phone | Show all posts
Jap tak fahammm, so depa cakap Pfizer/Moderna takde blood clot sbb mechanism nk produce protein dia lain lah kan?
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Post time 4-6-2021 10:49 AM | Show all posts
LadyCarefree replied at 4-6-2021 02:13 AM
So, Malaysia patut halt dulu AZ until AZ keluarkan version baru.

Dah nama pon volunter kan. Terserah.
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Post time 4-6-2021 11:14 AM | Show all posts
309 of the 33m! Prevalence ke tak?
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Post time 4-6-2021 11:22 AM | Show all posts
Edited by BicaraHatiku at 4-6-2021 11:23 AM
miszclassique replied at 4-6-2021 10:48 AM
Jap tak fahammm, so depa cakap Pfizer/Moderna takde blood clot sbb mechanism nk produce protein dia  ...

Ada tapi tak byk ....
The European Medicines Agency (EMA) said last week that there have been more than 300 cases of TTS associated with coronavirus vaccines worldwide, including 287 occurrences with AstraZeneca, 8 with Johnson & Johnson, 25 with Pfizer and 5 with Moderna.


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Post time 4-6-2021 11:35 AM | Show all posts
nazzse replied at 4-6-2021 11:14 AM
309 of the 33m! Prevalence ke tak?

309 tu manusia juga bukan haiwan. patutnya cari vaksin yang sesuai untuk certain group contoh high risk bg vaksin low impact  side effect. sedih nasib rakyat malaysia terpaksa harap berita luar negara. dalam negara cakap semua ok lah apa
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Post time 4-6-2021 11:36 AM | Show all posts
orang kat luar bermati2an nak buat research psl vaksin and side effect...
tapi kat sini main tala je...
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Post time 4-6-2021 11:41 AM From the mobile phone | Show all posts
Kena pnggil bang @blastoff masuk cni
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Post time 4-6-2021 11:43 AM | Show all posts
CiliPadiSedap replied at 4-6-2021 03:35 AM
309 tu manusia juga bukan haiwan. patutnya cari vaksin yang sesuai untuk certain group contoh high ...

Dah ada alternatif tapi banyak yg bengap. Vaksin China konon low class. Tapi bila Iphone keluar berator beli jugak made in China pon.


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Post time 4-6-2021 11:43 AM From the mobile phone | Show all posts
CiliPadiSedap replied at 4-6-2021 03:35 AM
309 tu manusia juga bukan haiwan. patutnya cari vaksin yang sesuai untuk certain group contoh high ...

Saintis MY buat research harapkan funding. Masalahnya funding pun dah kena cut. Nah harapkan funding gomen berapa sangat. So tunggu je lah research negara lain.

Dan di MY jgk since penerima dah sign consent form sebelum cucuk, so tak boleh nak saman gomen wlpun mati.
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Post time 4-6-2021 11:44 AM From the mobile phone | Show all posts
monreyes replied at 4-6-2021 11:36 AM
orang kat luar bermati2an nak buat research psl vaksin and side effect...
tapi kat sini main tala j ...

Kalu Kita pertikai Kita dtuduh x skolah Kak...
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Post time 4-6-2021 11:46 AM From the mobile phone | Show all posts
CiliPadiSedap replied at 4-6-2021 11:35 AM
309 tu manusia juga bukan haiwan. patutnya cari vaksin yang sesuai untuk certain group contoh high ...

Tpaksa lh Kita Cari info Dr luar..
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Post time 4-6-2021 11:52 AM From the mobile phone | Show all posts
LadyCarefree replied at 4-6-2021 10:13 AM
So, Malaysia patut halt dulu AZ until AZ keluarkan version baru.

Tu la..aku sebgai makhluk byk alergik ni mengharapkan gitu la..sbb mcm antiviral utk h1n1 ke apa sebelum ni..memula byk cases jgk..after sometimes scientists found the way out..so rsnya sama la dgn kes vaksin covid ni..
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Post time 4-6-2021 12:03 PM | Show all posts
nazzse replied at 4-6-2021 11:43 AM
Saintis MY buat research harapkan funding. Masalahnya funding pun dah kena cut. Nah harapkan fundi ...

bajet jkom ada pula ye? bajet untuk research tiada. hebat. next pru kaka xpg mengundi. kaka lockdown diri sendiri
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Post time 4-6-2021 12:04 PM | Show all posts
honeybee1802 replied at 4-6-2021 03:52 AM
Tu la..aku sebgai makhluk byk alergik ni mengharapkan gitu la..sbb mcm antiviral utk h1n1 ke apa s ...

Kau tanya @atira dia kan penyembah saintis.
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Post time 4-6-2021 12:05 PM From the mobile phone | Show all posts
pelik jugak kalau ada yang kata % yang mati atau kena blood clot ni sikit je berbanding ratusan ribu yang dah jab...

well russian roulette kah nyawa masing2?

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Post time 4-6-2021 12:07 PM | Show all posts
CiliPadiSedap replied at 4-6-2021 04:03 AM
bajet jkom ada pula ye? bajet untuk research tiada. hebat. next pru kaka xpg mengundi. kaka lockdo ...

U sekarang funding research cari sendiri kaka. Funding gomen, research tak sampai separuh jalan duit dah habis,pastu habiskan boras je lah selama buat tu. Rugi jadi saintis kat Malaysia, tak berkembang otak, gaji pun sikit, Baik jadi instafemes, cukup setahun boleh beli Merc, rumah landed eco majestic
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