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[Tempatan] Wow.... surat penerangan mengenai Ivermectin yg berjaya menyangkal DG

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Author: blastoff       Show all posts   Read mode

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Post time 12-6-2021 06:33 PM | Show all posts |Read mode
Edited by blastoff at 12-6-2021 06:37 PM

Apa yg DG cuba bangkitkan utk menimbulkan kesangsian ramai mengenai keberkesanan Ivermectin telah berjaya di sangkal dgn jayanyaaa dalam surat bawah ni .......Pekong DG dah terdedah keseluruh malaysia ...........yg dok percaya DG lani hanyalah pencacai2 dan segelintir rakyat yg termakan dakyah hasutan DG je

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https://www.malaysiakini.com/letters/575402

LETTER | Use of Ivermectin against Covid-19: Reply to Health DG

Wong Ang Peng et al

Published 20 May 2021, 1:37 am

LETTER | We respectfully disagree with Health director-general Dr Noor Hisham Abdullah when he stated on May 16, 2021, that there is no conclusive evidence for the use of Ivermectin against Covid-19.

We understand that the officials and staffs of MOH are currently overwhelmed with the rising infective and mortality rates of the disease. Our team of researchers are pleased to do the homework pointing to the numerous peer-reviewed scientific studies showing Ivermectin is effective prophylaxis and treatment for Covid-19.

Ivermectin has already been proven to be very safe as it has been used safely and successfully (to treat other tropical diseases) for over 40 years and by four billion people.

We feel that many people are dying every day and getting infected with Covid-19 so unnecessarily.

What have we got to lose in trying out a tried and tested medicine (Ivermectin), which is increasing being used in other countries against Covid-19 and its new variants, that has been proven very safe over and with many recent credible studies around the world confirming that it can reduce the risk of infection against Covid-19 by 88 percent and reduces the mortality rate by 83 percent? There is no official treatment protocol against Covid-19 at the moment.

The studies listed below are randomised controlled trials (RCT), considered the gold standard in evidence-based medicine, peer-reviewed, reproducible, using only Ivermectin and no add-on. Randomisation circumvents the problem with confounding, while the single investigative agent used without the add-on, ie, only Ivermectin, should leave no doubt that any positive result shown is specifically due to the investigative agent.

Most of the RCTs conducted on Ivermectin were of small and medium scale studies. This is not an issue if the trials were well designed and properly conducted, and the results show statistical significance.

Individual doctors who have no ulterior motive or vested interest other than altruistic intent, funded most of the studies. The above points answer the Health DGs criticism of the Ivermectin studies.

The following RCTs show positive results of Ivermectin on Covid-19:

Babalola et al (2021) in a double-blinded RCT of 62 patients found a significant difference in viral clearance between both the low-dose and high-dose treatment groups and controls.

Chaccour et al (2021) in a small double-blind RCT, randomised 24 patients to Ivermectin and placebo, found statistically significant decreases in viral loads, patient days of anosmia, and patient days with cough.

Elgazzar et al (2020) randomised four treatment groups of 100 hospitalised patients in each group. Groups 1 and 2 were mild to moderate illness patients given either ivermectin plus standard care or hydroxychloroquine plus standard care. Groups 3 and 4 were severely ill patients, either given Ivermectin plus standard care or hydroxychloroquine plus standard care. In both the groups given Ivermectin the rate of disease progression was lower. The mortality rate for the Ivermectin groups was also significantly lower.

Niaee et al (2020) in a randomised placebo-controlled multicenter trial at five hospitals found a dramatic reduction in mortality with Ivermectin use and also improvement in several other clinical parameters.

There are also observational controlled trials (OCT), although not considered the gold standard, nevertheless contribute significantly to the body of scientific knowledge regarding Ivermectin and its therapeutic usefulness. The followings are the OCTs:

Rajter et al (2020) performed a retrospective OCT on 280 consecutively treated patients and compared those treated with Ivermectin to those without and found statistically significant lower mortality among Ivermectin-treated patients. In a subgroup of patients with severe pulmonary disease, mortality was much reduced when treated with Ivermectin.

Khan et al (2020) compared 115 patients treated with Ivermectin to a standard care cohort of 113 patients and found that those receiving Ivermectin became SARs-CoV-2 negative more quickly, fewer developed respiratory distress, and had a shorter hospital stay. There was lower mortality rate in the Ivermectin-treated patients.

Portmann-Baracco et al (2020) in a large OCT that included nearly 1,500 patients reported that in 704 hospitalised patients treated with a single dose of Ivermectin, compared with 704 controls, overall mortality was reduced. For those patients on mechanical ventilation, mortality was also reduced (7).

There are a number of studies showing Ivermectins ability to prevent Covid-19. The followings are the prophylaxis studies:

Elgazzar et al (2020) randomised 200 healthcare workers and households who had contact with Covid-19 patients where the intervention group of 100 was given Ivermectin and wore personal protective equipment (PPE), and control of 100 wore PPE. The study found a large and statistically significant reduction in contacts testing positive by RT-PCR when treated with Ivermectin versus control.

Shoumann et al (2021) conducted an RCT involving family members of patients PCR-positive for Covid-19. The Ivermectin group included 203 contacts, while the non-intervention group included 101 contacts. Fifteen in the Ivermectin arm developed Covid-19 compared to 59 in the non-intervention arm after a two weeks follow up. The result also showed a large and statistically significant decrease in Covid-19 symptoms among household members treated with Ivermectin.

Alam et al (2020) conducted a prospective OCT at a hospital with 118 healthcare providers evenly divided into an experimental group receiving a single dose of Ivermectin 12 mg per month for four months, and the control group. Both groups were exposed to Covid-19 positive patients. Results of the symptomatic subjects and tested positive with RT-PCR showed 73.3 percent in the control group were positive for Covid-19 compared to only 6.9 percent in the experimental group.

Hellwig and Maia (2021) studied countries with routine mass drug administration including prophylactic Ivermectin and found that these countries have a significantly lower incidence of Covid-19. This reported correlation is significant to show a possible causal connection.

A few countries in South America provided good information supporting the role of Ivermectin in Covid-19 decreasing transmission rates. Countries like Peru, Brazil and Paraguay initiated the Ivermectin distribution programme for their citizens after their countries were hard hit by the pandemic in April 2020. Some cities started the Ivermectin programme earlier than others. Large decreases in the case count for the cities soon after receiving Ivermectin in comparison to those cities that started the campaign late.



Health director-general Dr Noor Hisham Abdullah

In evidence-based medicine (EBM), the systematic review and meta-analysis of RCTs occupy the top hierarchy of evidence. The study of Bryant et al (2021), Ivermectin for the prevention and treatment of Covid-19 infection: a systematic review and meta-analysis, included 21 RCTs involving 2,741 participants and meta-analysis conducted on 13 trials. The result showed Ivermectin reduced the risk of death compared to no Ivermectin. Ivermectin prophylaxis reduced Covid-19 infection by an average of 86 percent.

Dr Tess Lawrie (2021) conducted a systematic review and meta-analysis of 15 RCTs and 6 OCTs and confirmed that Ivermectin substantially reduced the risk of a person dying from Covid-19 by 83 percent. When used as a prophylaxis among healthcare workers and contacts, Ivermectin substantially reduced Covid-19 infection by 88 percent.

The studies mentioned above are all well-designed studies, peer-reviewed, and mostly RCTs, Not circumstantial hype as mentioned by the Health DG. There are several other studies, many of them RCTs that also include add-on therapeutic agent, case series, and poorly designed studies, studies having a certain degree of bias, and studies that did not consider for confounding factors; were omitted.

In short, the studies mentioned are all of high quality. There are also two systematic reviews and meta-analysis of RCTs. These are studies of the highest quality, the gold standard, and occupy the highest order of evidence in the evidence-based medicine.


With regards to dosage of Ivermectin, most of the studies mentioned used around 12mg in a single dose or an additional dose after a few days for the duration of the study. None used mega doses of Ivermectin, as news report quoting the Health DG had unwittingly implied.

Looking at the conclusion of the studies mentioned above, the evidence is compelling and appear conclusive that Ivermectin has prophylactic and therapeutic value.

The Health DG chose to look at two studies showing negative results on Ivermectin C Chaccour et al (2021) (2), and Lopez-Medina et al (2021) (16); of which we are happy to give counter views.

Chaccour and colleagues conducted a pilot RCT with the Ivermectin arm (a single dose of 400 mcg/kg (n=12) or placebo (n=12). All the subjects recruited had some mild symptoms of Covid-19. Although the Ivermectin group had non-statistically significant lower viral loads at day four and day seven, and also non-statistically significant lower IgG titers at day 21 post-treatment, the study results had clinical significance. Patients in the Ivermectin group recovered earlier from anosmia (loss of sense of smell), had reduced cough, lower viral loads and lower IgG titers, which are all positive signs. The reason for non-significant result is because the sample size was too small to show a large difference. Had the sample size ranged into thousands, the result would have been positive.

Lopez-Medina and colleagues conducted an RCT that included 476 patients with mild disease symptoms randomised to receive Ivermectin, 300mcg/kg of body weight per day for 5 days (n=200), or placebo (n=197). The primary outcome was time to resolution of symptoms within a 21-day period. The median time to resolution of symptoms was 10 days in the Ivermectin group compared with 12 days in the placebo group. By 21 days 82 percent in the Ivermectin group and 79 percent in the placebo group had resolved symptoms. The results showed no statistical significance.

The media had quoted the Health DG as saying the results (of Lopez-Medina study) showed there was no significant improvement in Covid-19 symptoms resolution time. This is incorrect. There is a big difference in the meaning of the word "significant" and "statistical significant". The proper words to use was the latter as it was a scientific study to compare one arm with the other, a relative comparison. The study also showed slightly less adverse events reported in the Ivermectin group compared to the control group C 77 percent vs 81.3 percent. For clinical purpose, the two days difference in symptoms resolution and the lesser adverse events are all significant.

Both the leading authors of the study disclosed they received grants and fees from two conglomerates that are also producing the mRNA vaccines that have been delayed in approval. From the way the trial was designed C relatively small sample size, types of outcome measure, age group of subjects, study duration; it appears the study was destined to turn negative.

Officials from our Health Ministry should look at the current scientific information pertaining to Ivermectin. Many RCTs on ivermectin and Covid-19 only got published in February and March 2021. The BMJ article, "Drug treatments for Covid-19: living systematic review and network meta-analysis", that was mentioned in the Health DGs statement was published in July 2020 with updated data as of April 6, 2021, as claimed.

However, in the report, there is no mention of Ivermectin trial results for mortality, adverse events leading to discontinuation, duration of hospital stay, ventilator-free days, and time to symptom resolution. Clearly there is selection bias in this BMJ report.

We have no malice in being critical of Health DGs statements. We are saddened to see the pandemic has claimed many lives, caused so much hardship, and used up so much of human and financial resources.

We genuinely believe, and are confident that if Ivermectin is mass-distributed, the epidemic in our country will be quickly brought under control.


The above statement is endorsed by:

Captain (Rtd) Wong Ang Peng, research scientist
Prof Mustafa Ali Mohd, senior pharmacologist & toxicologist
Dr Saifuzzaman Yusoff, medical doctor
Dr Zawawi Abdullah, medical doctor
Dr Durairajoo Govindarajoo, medical doctor
Nadzim Johan, chairperson, Coalition on Integrity of Vaccines & Drugs Against Covid-19 (Civdac)
Brig Gen (Rtd) Mohd Arshad Raji, Persatuan Patriot Kebangsaan (Patriot)
Abd Kadir Warsi Mohamad, Persatuan Pengguna Islam Malaysia (PPIM)
Police Commissioner (Rtd) Shabudin Abdul Wahab, Covid Research Centre (AHM Group)
Tunku Azwil Tunku Abd Razak, Gabungan NGO Islam (GNI)


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 Author| Post time 12-6-2021 06:43 PM | Show all posts
Edited by blastoff at 12-6-2021 06:45 PM

Taktik terbaru DG ialah halang orgramai dari beli Invermectin di pasaran online ....errr medical experts yg tersenarai kat atas tu bukannya snake oil salesmen sebaliknya betul2 experts lah haih , tapi kerajaan negeri melaka kata depa tak dak kelayakan lah plakkk .... so suddenly yg jual online ubat nih nak di siasat .... sepatutnya kerajaan yg distribute ubat tuh kannn dgn cara berhemah instead of nak halang penggunaannya plak .




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https://www.thestar.com.my/news/ ... -anti-parasite-drug

Do not trust "snake oil salesmen" promoting Covid-19 remedy using anti-parasite drug










  • NATION
  • Friday, 11 Jun 2021
    7:44 PM MYT


MELAKA: The state government has cautioned villagers from trusting snake oil salesmen trying to peddle the anti-parasite drug Ivermectin by claiming that it can prevent Covid-19.
State Rural Development, Flood Management and Green Technology Committee chairman Datuk Seri Idris Haron said villagers should not trust attempts to promote the drug on social media by these self-proclaimed "pharmacists".

Suddenly, there are online medical experts taking advantage of gullible villagers during this vulnerable period by claiming Ivermectin is an effective treatment for Covid-19. Its wrong to claim that Ivermectin is a panacea for the disease without the endorsement of the Health Ministry, he said.
Idris said in an interview on Friday (June 11) that villagers should lodge police reports on the allegations that the drug was being sold for RM200 for a box of 10 tablets.
Let the pharmacy enforcement division investigate this and those who are promoting this drug, he said.
Idris said the usage of Ivermectin for public and Covid-19 patients should be approved by the Ministry.
Ivermectin has been used for decades to treat head lice and river blindness in humans and heartworms in animals.
The drug first emerged in regards to Covid-19 treatment on April 3 last year when laboratory experiments done by researchers at Monash University of Australia found that Ivermectin in vitro had an inhibitory action on SARS-CoV-2, reducing the load of viral RNA by 5, 000 times in 48 hours.
On June 5, the ministry and the Institute for Clinical Research started clinical trials to study the use and efficacy of Ivermectin for high-risk Covid-19 patients at 12 hospitals.
Health director-general Tan Sri Dr Noor Hisham Abdullah said Ivermectin was a Food and Drug Administration (FDA) approved anti-parasitic drug, widely used for treating several neglected tropical diseases, including onchocerciasis, strongyloidiasis and helminthiasis.
However, he said the evidence was inconclusive to recommend routine use of Ivermectin for Covid-19 patients.
Dr Noor Hisham said the FDA has not approved Ivermectin for use in treating or preventing Covid-19 in humans and the World Health Organisation only recommends it in a clinical trial setting.



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Post time 12-6-2021 06:58 PM | Show all posts
kuti rancangan Selamat Pagi Malaysia (TV1) yang akan membicarakan topik COVID-19: Usaha Kajian Klinikal Keberkesanan Ivermectin bersama Dr Kalairasu M. Periasamy, Pengarah Institut Penyelidikan Klinikal (ICR), Institut Kesihatan Negara (NIH), KKM dan Dr Steven Lim Chee, Pakar Penyakit Berjangkit / Penyelidik Utama bagi Percubaan Klinikal (I-Tech Study), Hospital Raja Permaisuri Bainun, Ipoh.
Anda boleh ikuti rancangan ini pada Isnin, 14 Jun 2021 bermula jam 8 pagi.





https://www.facebook.com/kemente ... /10157989089146237/

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Post time 12-6-2021 07:00 PM From the mobile phone | Show all posts
mbhcsf replied at 12-6-2021 06:58 PM
kuti rancangan Selamat Pagi Malaysia (TV1) yang akan membicarakan topik COVID-19: Usaha Kajian Klini ...

Menarik ni. I bukan antivaks tp i trima any cara merawat yg terbukti boleh kurangkan kobid without any serious side effect. Ada kajian klinikal & all
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Post time 12-6-2021 07:00 PM From the mobile phone | Show all posts
Ye la tuuuuu
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 Author| Post time 12-6-2021 07:06 PM | Show all posts
mbhcsf replied at 12-6-2021 06:58 PM
kuti rancangan Selamat Pagi Malaysia (TV1) yang akan membicarakan topik COVID-19: Usaha Kajian Klini ...

Perbincangan yg hanya macam ulang tayang rekod rosak..... ulangggggg mende yg sama tuuuu lah ...tak berkesan bla bla bla tak cukup kajian bla bla bla......kau buat macam lah org tak faham keenganan guna ivermectin stem from nak jaga kroni pembuat vaksin tu haaaa hingga sanggup memperjudikan nyawa rakyat seluruh malaysia


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https://www.kosmo.com.my/2021/06/10/ivermectin-belum-terbukti-boleh-rawat-covid-19/


NEGARA

Gambar hiasan


Ivermectin belum terbukti boleh rawat Covid-19

  • Oleh NUR HUDA MUSA
  • 10 Jun 2021, 11:30 am


PETALING JAYA C Penggunaan ubat Ivermectin masih belum terbukti boleh merawat dan mencegah wabak Covid-19.
Kementerian Kesihatan (KKM) melalui Facebooknya berkata, Pertubuhan Kesihatan Sedunia (WHO) setakat ini juga hanya mengesyorkan penggunaan Ivermectin dalam ujian klinikal sahaja.
Belum ada bukti yang betul-betul meyakinkan bagi mengesyorkan penggunaan Ivermectin untuk merawat dan mencegah Covid-19.
WHO setakat ini hanya mengesyorkan penggunaan Ivermectin dalam ujian klinikal, di mana pesakit perlu dipantau rapi oleh doktor pakar dan penyelidik yang berpengalaman untuk menjamin keselamatan dan keberkesanan, katanya di sini hari ini.
Menurutnya, Ivermectin adalah ubat anti-parasit yang diluluskan oleh FDA dan kebiasaannya digunakan untuk haiwan dan bagi merawat beberapa penyakit tropika termasuk onchocerciasis, strongyloidiasis dan helminthiases.
Kajian Klinikal Ivermectin dalam rawatan Covid-19 di Malaysia sudah dilaksanakan bermula 31 Mei lalu oleh KKM dan Institut Penyelidikan Klinikal KKM melibatkan kira-kira 500 pesakit Covid-19 kategori 2 dan 3.
Terdahulu, Ketua Pengarah Kesihatan, Tan Sri Dr. Noor Hisham Abdullah menasihatkan orang ramai supaya tidak mengambil produk Ivermectin untuk rawatan dan pencegahan Covid-19 berikutan tiada data klinikal bagi membuktikan keberkesanan penggunaannya.
Beliau juga memberitahu Bahagian Regulatori Farmasi Negara (NPRA) memaklumkan setakat ini tiada produk dengan bahan aktif Ivermectin berdaftar dengan Pihak Berkuasa Kawalan Dadah (PBKD) untuk kegunaan manusia. C K! ONLINE




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Post time 12-6-2021 07:08 PM | Show all posts
blastoff replied at 12-6-2021 07:06 PM
Perbincangan yg hanya macam ulang tayang rekod rosak..... ulangggggg mende yg sama tuuuu lah ...ta ...

tu platform dah ade , tanya je lah pakar  pakar tu
tak perlu takut pun

sebab you paling lantang, tu dah ada platform , so napa nak defensive?
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 Author| Post time 12-6-2021 07:09 PM | Show all posts
Edited by blastoff at 12-6-2021 07:11 PM

31 mei buat ujian clinical ....... 10 jun kluar kat news yg ubat tu tak berkesan ...... 10 hari tuuu goyang apa kat clinical trial itteww ? Telor ayam kaaa ?

Ubat ivermectin dah boleh tengok keberkesanannya yg kat ICU tuuu dalam masa 48 saja maaa, tak perlu 10 hari punggg.... tu menunjukkan memang tak nak guna lah tuuu sebenarnya dan clinical trial yg dijanjikan tuuu cuma penipuan semata utk melengahkan penggunaan ubat tu selama mungkin ler agar lagi ramai boleh mati di ICU2 seluruh malaysia
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Post time 12-6-2021 07:10 PM From the mobile phone | Show all posts
Dipersilakan @dodolgemok masuk ke gelanggang perbahasan.

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 Author| Post time 12-6-2021 07:11 PM | Show all posts
Edited by blastoff at 12-6-2021 07:13 PM
mbhcsf replied at 12-6-2021 07:08 PM
tu platform dah ade , tanya je lah pakar  pakar tu
tak perlu takut pun

you yg defensive..... dah ada penerangan melalui surat tuu yg dah memperjelaskan segalanyaaaa buat pe kau nak aku pi buang masa bersoal jawap dgn pencacai2 DG plak ?

Segala kajian yg dah di buat selama nih valid kaw kaw maaa tapi kau dan DG tolak mentah2 nyaaa, kenapa aku plak kau nak jadikan pencacai utk dengar pembohongan korang ? Boleh gi mampusss lah dakyah khurafat korang tu , dasar tarak hati perut dok menyiksa manusia kat ICU
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Post time 12-6-2021 07:13 PM From the mobile phone | Show all posts
blastoff replied at 12-6-2021 07:09 PM
31 mei buat ujian clinical ....... 10 jun kluar kat news yg ubat tu tak berkesan ...... 10 hari tuuu ...

Semua kesembuhan ituu adalah dgn izinNYa jua..
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 Author| Post time 12-6-2021 07:14 PM | Show all posts
tipahketipung replied at 12-6-2021 07:10 PM
Dipersilakan @dodolgemok masuk ke gelanggang perbahasan.

berapa ratus MN depa hada haaaa   pi mai pi mai ciri posting SAMA SAJA MAAA asyik dok ulang perkataan bodoh dgn membebel tak ketahuan . Same ole same ole je walau MN berbeza yg dok masuk thread haku
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Post time 12-6-2021 07:15 PM | Show all posts
blastoff replied at 12-6-2021 07:11 PM
you yg defensive..... dah ada penerangan melalui surat tuu yg dah memperjelaskan segalanyaaaa buat ...

i cuma letak Siri rancangan selamat pagi malaysia.

i galakkan u tanya dedepan masa rancangan tu, so why dok kata alaaa itu ini. hey dalam forum u lantang then org bagi platform tanyalah pakar.


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 Author| Post time 12-6-2021 07:16 PM | Show all posts
cikmouse replied at 12-6-2021 07:13 PM
Semua kesembuhan ituu adalah dgn izinNYa jua..

tapi dinafikan kewujudan kesembuhan itteww ... bermakna menafikan kekuasaan Allah yg menyembuhkan lah
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Post time 12-6-2021 07:18 PM | Show all posts
blastoff replied at 12-6-2021 07:11 PM
you yg defensive..... dah ada penerangan melalui surat tuu yg dah memperjelaskan segalanyaaaa buat ...

SEKARANG ni u pun baru berani copy paste surat yg ada evidence based hahaha selama ni i tengok dok copy paste bang kok post , sporad c study . bila i post dalam satu thread you evidence based then hari ni wah wah evidence based.






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 Author| Post time 12-6-2021 07:18 PM | Show all posts
mbhcsf replied at 12-6-2021 07:15 PM
i cuma letak Siri rancangan selamat pagi malaysia.

i galakkan u tanya dedepan masa rancangan tu ...

bla bla bla aku dan DG betul bla bla bla kau dan sesiapa saja yg tak mahu mengakunya tak betul bla bla bla .........rekod rosak tuuu elok pi baiki ok
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Post time 12-6-2021 07:19 PM | Show all posts
Kalau betul la ko tau semua ttg ubat ni, go to the right channel,
Tanya kt situ.
Bg hujah2 kau.
Bising sampai pat belas ratus thread kt dalam ni ttg ko punye artikel copy paste ni ko dpt ape?
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Post time 12-6-2021 07:20 PM From the mobile phone | Show all posts
ni namanya..masa sayang dihargai...tiba2..terjumpa lak salah...terus dibenci....
ganti org lain ...ke nak mcm mana..
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Post time 12-6-2021 07:22 PM From the mobile phone | Show all posts
blastoff replied at 12-6-2021 07:16 PM
tapi dinafikan kewujudan kesembuhan itteww ... bermakna menafikan kekuasaan Allah yg menyembuhkan  ...

Aku nk dengo dlu apa kata pakar tempatan kita dlm program ituuu..
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Post time 12-6-2021 07:25 PM | Show all posts
blastoff replied at 12-6-2021 07:18 PM
bla bla bla aku dan DG betul bla bla bla kau dan sesiapa saja yg tak mahu mengakunya tak betul bla ...

now u talking about evidence based

u noticed tak something is lacking dalam surat tu
and u tak nak tanya mereka yg signed surat tu ke

satu soalan sebab i dok check something? but u nampak tak satu benda yg i tercari cari dalam surat tu ?
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