[MERGED] ALL ABOUT HEPATITIS

Dr.

cam ner kalau dah disahkan mengidap hepatitis A n B??
buat masa ni tak der apa-apa tanda pada diri saya...
cuma hasil ujian darah mengatakan saya mengidap Hepatitis A n B


[ Last edited by  blackmore at 24-3-2009 20:15 ]

Acong

Originally posted by sunsweet78 at 5-10-2003 05:21 PM:
Dr.

cam ner kalau dah disahkan mengidap hepatitis A n B??
buat masa ni tak der apa-apa tanda pada diri saya...
cuma hasil ujian darah mengatakan saya mengidap Hepatitis A n B

huhu! Buat pengetahuan sunsweet78, Hep A very common among asean ppl! This include Hep B... But Hep B complications are more severe when compared to Hep A.

I find the info for you! (Later lah!)

My advice to you are to have all your intimate friends and family members to get Hep B screening test (HBsAg and HBsAb) as soon as possible. Those without the antibodies for Hep B are recommended to get vacination from your family doctor.

The price for Hep B screening test (HBsAg and HBsAb) per person would not exceed RM30.00. Kowang boleh buat test lagi murah jika hanya test untuk Hep B Antigen aje. Lebih baik buat dua test skali! Kalu dah ader keimunan terhadap Hep B, takyah buat vaksinisasi Hep B!

Acong

Ujian darah ko nie ader buat second test tak? Kalu buat kat private lab, diorang akan recommend 2nd test! (No diskaun even 4 2nd test)


P/S - Ko buat test kat mana? Lab nama pe? PM haku!

I very scare of hepatitis ni! so no seafood for me.

Acong

Originally posted by bj at 6-10-2003 08:46 AM:
I very scare of hepatitis ni! so no seafood for me.

Normally asean ppl ader keimunan terhadap Hep A. Tak perlu la risau sgt! Huhu!

mbhcsf

what you got to do now .
is to consult a gastroenterologist
ask the path lab dr to buat something and then kalau verified sial gi jumpa doktor PAKAR ..please
jangan lengah. okay
bless you dan dapatkan infohealth dr authorised resources. okay
ini pada saya perlukan attention .yg serius.so tolong jgn ambil mudah.
Hep B virus is too virulent easily / highly contagious.
saya nak bagitau lebih pun  saya tak berani sbb tak ader authority so , saya harap gi dr then jumpa dr PAKAR ..tolong ..tolonglah....  i wish you all the  best ...okay ....

Acong

Banyak test lagi kena buat kalu Hep B Ag positif. Kena jugak buat viral load. Lab lain tak tau ader offer tak. Tapi haku tau ader satu lab ader offer test nie. Ko try call lab tu and tanya la! seelok2nya ko buat test secepat mungkin kerana antara satu complication Hep B ni effect ko punya liver [hati].

louiektc

sunsweet78,

The test sometimes contains mistake which is widely reported in the region. Please see if your can share your last test result and we couldl help to interpret. I am interested in HBeAb, AST(GOT), ALT(GPT and AFP level.

Secondly as posters earlier on mentioning, go for second test especially test on few items below to determine if you are a carrier or temporary infected.
1. HBsAg and HBsAb.
2. HBcAg and HBcAb.
3. HBeAg and HBeAb.
    Combination of the above test result.
In additional.
4. Sonar scan on liver morphology.

If you are a carrier proceed with HBV-DNA test to see if the HBV (virus) is activly mutiplying or inactive. The threshold is less than 0.005pg/ml or (<500copies).

NOTE: DO NOT take any anti-HepB drug such as Lamivudine and alpha interferon before advised by your medical advisor to do so. You may lost total control over the virus once mutation taken place in its DNA's chain. 2 drugs mentioned above are the only solution capable to supress HBV from multiplying in a period of 9 months usage. The curable success rate is ~15 to 25% for Asian and is reported more than 30% for westerners. The only way now is to get your chirdren go for HBV-DNA screening immediately until they develop sufficient antibody level for the monitoring period of every 5 years. For the carriers, there is no curable medicine available but by practising healthy life style means more to you. Notify your doctor before delivery a new born, get infant a zap of Anti Heb dose within first 24 hours to avoid bleeding infection.

1. Reduce oilly and fried food.
2. Avoid fungi contains food.
3. Avoid alcohol and artificial food additive.
4. Avoid peptesite vegetable.
5. Sleep well and have quality sleep.
6. Avoid hormone injected meat such as chicken, beef, pork. Get the protein source from soya milk and deep sea fishes..

Do not worry, there is no suddent death if follows above suggestions and probably other probability of death is much higher than HepB. say cancer, diabetis and high blood pressure or Aids.

[ Last edited by louiektc on 6-10-2003 at 11:40 PM ]

Acong

Originally posted by sunsweet78 at 5-10-2003 05:21 PM:
Dr.

cam ner kalau dah disahkan mengidap hepatitis A n B??
buat masa ni tak der apa-apa tanda pada diri saya...
cuma hasil ujian darah mengatakan saya mengidap Hepatitis A n B

You should also stop smoking, if you smoke.

louiektc

Acong, you are right, stop smoking too..

Here is the tips help you to interpret the test result.

Typical standard Liver function tests major indices as below.
1. Bilirubin total and Bilirubin direct to detect the yellow desease.
2. AST(GOT) and ALT(GPT) to indicate the liver functioning level.
3. Alkaline phospates (Alk-P)
4. Gamma Glutamyl transferase (GGT)
5. Albumin to Globulin ratio to measure protein synthesis capability.
6. Protein total
7. TTT and ZTT to indicate the harden liver.
8. Cholestral total
9. Prothrombin time
10. Platelet
11. Alpha Fetoprotein (AFP) to detect the present of liver cancer.
12. LDH.

Below is the guideline how to interpret Ant7igen or antibody test result.
HBsAg HBsAb HBeAg HBeAb  HBcAb HBV-DNA  Meaning
+             -        +        -         +          +        HBV infected, carrier and high risk
+             -        -         +        +          -         HBV inactive, Antibody &#8211;e present
+             -        -         +        +          +        HBV mutation detacted. GOT/GPT unstable.
-             +        -         +        +           -        HBV stops mutiplying, immuned to HBV.
-             +         -         -         -           -        Antibody developed, periodic tracing recommended.

thanks for your information...

tengah tunggu result 2nd test/..

aikon

boleh ker time pregnant amik jab ni???...ada certain ppl kata tak boleh...and ada doc yg i consult kata boleh...pastu certain ppl said that u cannot pregnant selepas amik 1st jab tu...camna ni??...ada sesape tau tak??...explain please....TQ

Acong

Safety and immunogenic response in mothers and antibody transfer to neonates.

By Reddy PA, Gupta I, Ganguly NK @ Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Hepatitis B infection during pregnancy causes increased, maternal morbidity and perinatal mortality. No specific therapy is available, hence neonatal immunoprophylaxis is recommended by WHO. However, the advantages of maternal immunization are manifold. Therefore, 15 pregnant HBsAg negative women were studied after 3 dozes of hepatitis B specific vaccine. No untoward effects of vaccine were observed and a good immunogenic response with very high antibody titres 178 IU/l and 184 IU/l at delivery and 3 months post delivery respectively were noted. Passive transfer of antibodies to the neonates was 100% at birth but these levels declined rapidly. Hence hepatitis B specific vaccine is safe and immunogenic in pregnant women and protects their babies in the immediate neonatal period.

PMID: 7832667 [PubMed - indexed for MEDLINE]

Acong

Hepatitis B is caused by a DNA virus, and the intact virus is termed the Dane particle. The virus has three major structural antigens: surface antigen (HBsAg), core antigen (HBcAg), and e antigen (HBcAg).

Following an acute infection caused by hepatitis B virus, less than 1 percent of patients develop fulminant hepatitis and die. Eighty-five to 90 percent experience complete resolution of their physical findings and develop protective levels of antibody. Ten to 15 percent of patients become chronically infected. Of these, 15 to 30 percent subsequently develop chronic active or persistent hepatitis or cirrhosis, and about 20 per cent of those with cirrhosis will develop hepatocellular carcinoma. Hepatocellular carcinoma is one of the most common cancers worldwide. Chronic liver disease is particularly likely to occur in patients who remain seropositive for HBsAg and who become superinfected with the hepatitis D virus.

The diagnosis of acute hepatitis B is confirmed by detection of the surface antigen and IgM antibody to the core antigen. Identification of HBeAg is indicative of an exceptionally high viral inoculum and active viral replication. Patients who have chronic hepatitis B infection have persistence of the surface antigen in the serum and liver tissue. Development of anti-HBs (antibody to Hep B surface antigen) indicates immunologic response to infection and cure.

Perinatal transmission occurs primarily as a result of the infant's exposure to infected blood and genital secretions during delivery. In the absence of immunoprophylaxis for the neonate, perinatal transmission occurs in 10 to 20 percent of women who are seropositive for HBsAg. The frequency of perinatal transmission increases to almost 90 percent in women who are seropositive for both HBsAg and HBeAg.

Fortunately, a combination of passive and active immunization is highly effective in preventing both horizontal and vertical transmission of hepatitis B infection. Results with the use of hepatitis B immunoglobulin for prophylaxis in babies at risk of infection with HBV are encouraging if the immunoglobulin is given as soon as possible after birth or within 12h of birth; the chance of the baby developing the persistent carrier state is reduced by about 70 per cent. More recent studies using combined passive and active immunization indicate an efficacy approaching 90 per cent. The dose of hepatitis B immunoglobulin recommended in the newborn is 1 to 2ml (200 i.u. antiHBs/ml).

Infants who are delivered to seropositive mothers should receive HBIG, 0.5 ml IM, immediately after birth. They then should begin the hepatitis B vaccination series within 12 hours of birth. At the present time, two recombinant hepatitis B vaccines are available, Recombivax-HB and Engerix-B. Both products are composed of inactivated portions of the surface antigen and are prepared by recombinant DNA technology. Neither poses a risk of transmission of a blood-borne pathogen, and both are safe for administration during pregnancy to patients at risk.

Neonatal immunoprophylaxis is approximately 85 to 95 percent effective in preventing neonatal hepatitis B infection. In view of the extremely favorable results of immunoprophylaxis, the Centers for Disease Control and Prevention (CDC) recently recommended universal hepatitis B vaccination for all infants.

Obstetricians must screen all of their patients for hepatitis B at some point during pregnancy. Selective screening on the basis of acknowledged risk factors will fail to identify 30 to 50 percent of seropositive women.

Actual Link!

aikon

Originally posted by Acong at 2003-10-15 12:04 PM:
Safety and immunogenic response in mothers and antibody transfer to neonates.

By Reddy PA, Gupta I, Ganguly NK @ Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Educa ...

so maknanyer takde effect ker??...still confius...ai dah buat blood test bulan 7 ari tu...and -ve hep a or b...cuma takde antibodi jek...thats why ai amik jab tu...sekang tgh tunggu 3rd jab plak...so kalau terpregnant ok ek??...

p/s Acong ni doc ker???...

Acong

Originally posted by aikon at 15-10-2003 01:32 PM:
so maknanyer takde effect ker??...still confius...ai dah buat blood test bulan 7 ari tu...and -ve hep a or b...cuma takde antibodi jek...thats why ai amik jab tu...sekang tgh tunggu 3rd jab plak... ...

takde masalah. kalu ader complication, awal2 doktor ko dah bagi tau. yang haku ingat cuma vaksinasi untuk rubella je akan effect kat pregnancy. so, all 'da best!

louiektc

aikon,
Usually Hep B transmites verticlly to infant during that blood breaking moment. At this point of time Hep B is not curable desease but is controllable thru specific diet and life style. At this moment, It is more important to safe the infant by having him a zap in his very first 24 hours after born. Make sure you put up the request to your doctor.

Then seek the advise of doctor on your body resistance to Hep B later to determine your ability to develope antibody against it or become a carrier.

Thanks again Acong for the posting.
I only have one comment on below statement.
"Hepatitis B is caused by a DNA virus, and the intact virus is termed the Dane particle. The virus has three major structural antigens: surface antigen (HBsAg), core antigen (HBcAg), and e antigen (HBeAg)."

This statement refers to a active Hep B virus which having the size at 42nm consisting DNA that allows multipying. It will turn to Hep inffection once body failed to generate antibody. The Antibody mentioned would be HB(s,c,e)Ab. While the present of HBsAg or HBcAg does not guaranty that HBV-DNA is active. It is because, those antigen also present in other inactive capsule form of 22x42nm which lacking of HBV-DNA. It is more precise to carry out the test of all four elements in earlier detection of Hep B immunasation or carrier

i know this post must hv been posted earlier..but i am a new user here.

I am 19 yrs old and i only found out that i am the Hb B carrier last year. I really worry about my health. Please anyone here can tell me what can i do. What is the most suitable diet for us? What should i do to recover fully? Most importantly is it curable?

I believe the basis of the diagnosis was based on a repeat testing of your blood (at least 6 months interval) and the finding of a persistence of the HBsAg and negative for HBsAb. What is the status of your HBeAg as its presence will indicate that your blood and other body fluids are highly infectious.

The complications of a chonic HBV infection are many but the ones more feared are 1. development of liver cancer (estimated to be 200x more than non-carriers), 2.liver cirrhosis and 3.subsequent liver failure.

The blood from a HBV carrier is 100x moreinfectious than theblood of someone with HIV infection. You must refrain from donating blood and take precautions not to engage in unsafe sex in order not to pass the infection on to your partner.

If you are a female and is in your reproductive age, you run the risk of transmitting the infection to your newborn baby, who will in turn develop a chronic carrier state like you.

Refrain from alcohol consumption,tobacco smoking, and eat a healthy, balanced diet so as not to subject the liver to extra stress. Do not take drugs/medications or herbs that are potentially toxic to the liver.

It is advisable for someone with chronic HBV infection to do a yearly ultrasound of the liver (to look for early signs of liver cancer and development of cirrhosis (hardening of liver)) and an annual blood test (alpha-fetoprotein) as a marker of liver cancer.

There is no cure for chronic HBV infection but monitoring of your liver function (via blood tests) will tell if your liver's function is deteriorating. In those will abnormal liver function tests you can do a HBV-RNA test to estimate the viral load in the body. If there are indications to treat, then Lamivudine and interferon can be started to control the viral replication. However, the treatment is quite expensive and the viral load goes up when treatment is stopped.

For prevention of HBV infection your spouse and close contacts should get vaccinated with the hepatitis B vaccine which is very safe and effective.

For more information visit the  Malaysian Liver Foundationwebsite

salam....

saya mintak maafle kalau soalan ini pernah keluar kat forum ni,

saya nak tanya pendapat doktor dan kengkawan di sini, kawan saya satu pejabat mengidap Hepatitis B, sekarang ni dah bertugas semula dan katanya dia dah beransur pulih, kawan lain ader yangbagitau penyakit ini boleh berjangkit, betul ke? kalau boleh berjangkit macammana caranya jangkitan itu? dan bagaimana nak mengelakkan jangkitan tersebut. Harap dapat jawapan dari kawan kat sini,

terima kasih....